4-Methoxy-α-bromoacetophenone (also known as 2-Bromo-4'-methoxyacetophenone) is a key brominated aromatic ketone widely used as a pharmaceutical intermediate, particularly in the synthesis of protein tyrosine phosphatase (PTP) inhibitors with anti-angiogenic activity (IC₅₀ = 3.7 μM). This compound exhibits a melting point of 69-71°C (lit.) and boiling point of 306.7±17.0°C at 760 mmHg, with a density of 1.4±0.1 g/cm³ and refractive index of 1.554. It should be stored sealed at 2-8°C in dry conditions. As a reactive α-bromoketone, it participates in various nucleophilic substitution reactions. Safety precautions include wearing protective equipment due to its irritating properties (GHS Category 2).
