2-Chloro-3-amino-4-methyl pyridine

2-Chloro-3-amino-4-methyl pyridine

CAS No.: 133627-45-9
Molecular Formula: C₆H₇ClN₂
Molecular Weight: 142.59
Appearance: White to light yellow crystalline powder
Purity: ≥98% (HPLC)
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Product Description

2-Chloro-3-amino-4-methylpyridine is a key pharmaceutical intermediate primarily used in the synthesis of nevirapine (an antiretroviral drug for HIV treatment). This heterocyclic compound features a melting point of 118-121°C (lit.) and boiling point of 295.9±23.0°C at 760 mmHg. With a density of 1.26±0.1 g/cm³ and pKa of 6.72±0.10, it demonstrates good solubility in polar organic solvents. The material should be stored in airtight containers at 2-8°C, protected from light and moisture. Safety precautions include wearing protective gloves/eyewear due to potential skin/eye irritation (GHS Category 2). Its unique pyridine structure with chloro and amino substituents makes it valuable for constructing complex drug molecules.

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