S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine is a key chiral intermediate for the synthesis of duloxetine hydrochloride, a widely used antidepressant. This compound features a thiophene ring and a β-hydroxy amine structure, with a melting point of 78-80°C and boiling point of 290.1±30.0°C at 760 mmHg. It has a density of 1.1±0.1 g/cm³ and refractive index of 1.553. The material should be stored sealed in dry conditions at 2-8°C, protected from light. Safety precautions include wearing protective gloves and eye/face protection due to potential skin/eye irritation (GHS Category 2). Its (S)-configuration is crucial for pharmaceutical activity in serotonin-norepinephrine reuptake inhibitors.
