2-Thiophenecarboxaldehyde (2-Thiophenealdehyde) is a key heterocyclic aldehyde widely used as a pharmaceutical intermediate, notably for synthesizing the broad-spectrum anthelmintic Pyrantel and cephalosporin antibiotics (Cephalosporin I/II). This viscous liquid has a boiling point of 198°C, density of 1.215 g/cm³ (21°C), and refractive index of 1.592. It exhibits slight solubility in water but is miscible with ethanol/ether. Storage requires nitrogen protection at 2-8°C due to its air sensitivity. The compound is classified as harmful if swallowed (GHS Category 4) and may cause skin sensitization (GHS Category 1B), necessitating proper ventilation and PPE during handling.
