3-Acetyl-2,5-dichlorothiophene is a halogenated thiophene derivative widely used as a key intermediate in pharmaceutical synthesis, particularly for carbonic anhydrase inhibitors like brinzolamide. This compound exhibits a melting point of 37-40°C (lit.) and boiling point of 120-122°C at 4 mmHg. It has a density of 1.451 g/cm³ (est.) and should be stored under inert atmosphere at 2-8°C, protected from light. The acetyl and dichloro functional groups make it highly reactive for nucleophilic substitution and coupling reactions. Safety precautions include wearing protective equipment due to its irritant properties (GHS Category 2).
