2,3-Dichlorothiophene-5-sulfonyl chloride is a reactive sulfonyl chloride derivative primarily used as a key intermediate in pharmaceutical synthesis, particularly for LecB inhibitors and MTH1 inhibitors. The compound has a melting point of 54-58°C (lit.) and predicted boiling point of 338.7±42.0°C at 760 mmHg, with a density of 1.803±0.06 g/cm³. It should be stored sealed at 2-8°C under inert atmosphere due to moisture sensitivity. Safety precautions are critical (UN 3261, Packing Group II) as it reacts violently with water releasing toxic gases (HCl/SO₂). Handling requires acid-resistant PPE and adequate ventilation.
