2-Chloro-5-formylthiophene is a key heterocyclic aldehyde intermediate widely used in pharmaceutical synthesis, particularly for thiophene-based drug candidates. This compound features a melting point of 48-52°C (lit.) and boiling point of 250-252°C at atmospheric pressure. The aldehyde functionality at the 5-position enables diverse condensation reactions, while the 2-chloro substituent facilitates further functionalization. Storage should be in airtight containers under inert atmosphere at 2-8°C to prevent oxidation. Safety precautions include wearing protective gloves/eyewear due to potential skin/eye irritation (GHS Category 2). Its unique structure makes it valuable for constructing bioactive molecules with improved metabolic stability.
