![2-(4-Hydroxyphenyl)-benzo[B]thiophene-6-ol](/upload/20251120/d163e60e9a2b3c8dfdaa5352910a9abc.png)
2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol is a key pharmaceutical intermediate and estrogen receptor modulator (SERM). It demonstrates selective estrogen receptor binding activity with pIC50 of 0.46, showing potential in treating tamoxifen-resistant tumors. The compound melts at 295°C (dec.) and has a predicted boiling point of 477.0±30.0°C. Storage requires protection from light at -20°C. As a bifunctional phenolic compound, it serves as the core structure for raloxifene synthesis. Safety precautions include handling with protective equipment due to potential hormonal activity.
