Thiophene-α-sulfonamide (2-Thiophenesulfonamide) is a heterocyclic sulfonamide compound widely used as a pharmaceutical intermediate, particularly in the synthesis of thiophene-based bioactive molecules. It exhibits a melting point of 145-146°C (lit.) and boiling point of 338.1±34.0°C at 760 mmHg. The compound is soluble in methanol and DMSO but insoluble in water, with a predicted density of 1.513 g/cm³ and pKa of 9.94±0.60. Storage should be in sealed containers under dry conditions at room temperature. Safety precautions include wearing protective equipment due to potential irritation (GHS Category 2). Its thiophene core and sulfonamide functionality make it valuable for constructing CNS drugs and enzyme inhibitors.
