5-Chlorothiophene-2-sulfonyl chloride is a reactive sulfonyl chloride derivative widely used in pharmaceutical synthesis, particularly as a key intermediate for antiplatelet drugs (e.g., Enogrel). This moisture-sensitive compound decomposes in water, releasing HCl gas. It exhibits a melting point of 25-28°C, boiling point of 112-117°C (lit.), and density of 1.623 g/cm³ (25°C). Storage requires sealing under inert gas (N₂/Ar) at 2-8°C. Handling demands corrosion-resistant PPE (GHS Category 1B) due to severe skin/eye corrosion hazards (UN 3265, Packing Group II). The sulfonyl chloride group enables efficient conversions to sulfonamides or sulfonate esters under mild conditions.
