2-Acetylthiophene is an important heterocyclic compound widely used as a pharmaceutical intermediate, notably in the synthesis of cephalosporin antibiotics (e.g., cefotaxime sodium). This liquid exhibits a characteristic aromatic odor with a melting point of 10-11°C, boiling point of 213.5°C (760 mmHg), and density of 1.168 g/mL at 25°C. Its refractive index is 1.565 (n20/D) with moderate solubility in organic solvents but low water solubility. Storage requires protection from light in cool, well-ventilated areas. Safety precautions include using chemical-resistant gloves (GHS Category 2) due to skin/eye irritation potential. The compound serves as a key building block for thiophene-based agrochemicals and electronic materials.
