2-Acetyl-5-bromothiophene is a brominated thiophene derivative widely used as a pharmaceutical intermediate, particularly in the synthesis of protease inhibitors and antibacterial agents. This compound exhibits a melting point of 94-96°C (lit.) and boiling point of 103°C (4 mmHg), with a density of 1.619 g/cm³ and refractive index of 1.583. The material should be stored under inert gas (nitrogen/argon) at 2-8°C, protected from light due to photosensitivity. Safety precautions include wearing protective gloves/eyewear as it may cause skin/eye irritation (GHS Category 2). Its unique structure combining acetyl and bromo groups on the thiophene ring makes it valuable for constructing heterocyclic drug molecules.
