S-Phenyl Thioacetate is an aromatic thio-ester in which an acetyl group is directly linked to a phenylthio (PhS) moiety. It is air-stable, freely miscible with common organic solvents (dichloromethane, ethyl acetate, toluene, alcohols) and essentially insoluble in water. Commercial material is supplied ≥98 % pure.
Key physicochemical data:
Density: 1.11 g cm⁻³ (25 °C)
Refractive index n²⁰/D: 1.570
Boiling point: 224 °C / 760 mmHg
Flash point: 89 °C (closed cup)
Log P (octanol/water): 2.1 (predicted)
Typical uses:
Acyl-transfer reagent for the introduction of the PhS–CO– group; building block for hetero-aryl thio-esters.
Precursor for phenylthio-ketones, sulfoxides and sulfones used in pharmaceutical and agro-chemical synthesis.
Model substrate for enzymatic thio-ester hydrolysis and acyl-transfer mechanistic studies.
Quality specification (commercial grade):
Purity (GC): ≥98 %
Water content (KF): ≤0.2 %
Free acid (as thiophenol): ≤0.1 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Causes skin and eye irritation (H315 + H319). Avoid inhalation of vapour; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants and strong bases. SDS available on request .
