Cyclopropyl phenyl sulfide is a mixed alkyl–aryl thio-ether in which a cyclopropyl group is directly attached to sulfur. The compound is air- and photo-stable, freely miscible with common organic solvents (dichloromethane, ethyl acetate, toluene, alcohols) and essentially insoluble in water. Commercial material is supplied ≥98 % pure.
Key physicochemical data:
Density: 1.06 g cm⁻³ (25 °C)
Refractive index n²⁰/D: 1.586
Boiling point: 225 °C / 760 mmHg (predicted)
Flash point: 90 °C (closed cup)
Log P (octanol/water): 3.4 (predicted)
Typical uses:
Versatile building block for cyclopropyl sulfoxide/sulfone pharmaceutical intermediates and agro-chemicals.
Precursor for sulfur-stabilised cyclopropyl carbanions used in ring-opening and cyclisation protocols.
Model substrate for mechanistic studies on strained C–S bond activation and radical cyclisation reactions.
Quality specification (commercial grade):
Purity (GC): ≥98 %
Water content (KF): ≤0.2 %
Free thiol (as PhSH): ≤0.1 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Causes skin and eye irritation (H315 + H319). Avoid inhalation of vapour; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants. SDS available on request.
