4-Phenylthio benzaldehyde is an aromatic aldehyde bearing a phenylthio group para to the formyl function. The compound is air-stable, freely soluble in dichloromethane, ethyl acetate, hot ethanol and toluene, and practically insoluble in water. Commercial material is supplied ≥98 % pure.
Key physicochemical data:
Melting point: 98–100 °C (lit.)
Boiling point: 398 °C / 760 mmHg (predicted)
Density: 1.23 g cm⁻³ (25 °C, solid)
Flash point: >200 °C
Log P (octanol/water): 4.1 (predicted)
Typical uses:
Versatile building block for thio-chalcone, thio-stilbene and thio-aniline derivatives via aldol, Knoevenagel or reductive amination protocols.
Precursor for sulfoxide/sulfone-containing optical brighteners, UV-absorbers and pharmaceutical intermediates.
Model substrate for mechanistic studies on aromatic aldehyde oxidation and disulfide-mediated radical reactions.
Quality specification (commercial grade):
Purity (HPLC): ≥98 %
Water content (KF): ≤0.3 %
Free acid (as benzoic acid): ≤0.5 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Causes skin and eye irritation (H315 + H319). Harmful if swallowed (R22). Avoid inhalation of dust; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants and strong bases. SDS available on request.
