![4-Methoxy-a-[(3-Methoxyphenyl)thio] Acetophenone](/upload/20251022/e6ec6a72085151e1c437544adc351e57.png)
4-Methoxy-α-[(3-methoxyphenyl)thio]acetophenone is an aromatic ketone bearing a methoxy group para to the carbonyl and a (3-methoxyphenyl)thio substituent at the α-position. The compound is air-stable, freely soluble in dichloromethane, ethyl acetate, hot ethanol and toluene, and practically insoluble in water. Commercial product is supplied ≥98 % pure.
Key physicochemical data:
Melting point: 112–115 °C (lit.)
Predicted b.p.: 458 °C / 760 mmHg
Density: 1.24 g cm⁻³ (25 °C, solid)
Flash point: >200 °C
Log P (octanol/water): 4.1 (predicted)
Typical uses:
Versatile building block for α-thio-β-methoxy-chalcone derivatives with potential anti-inflammatory or anti-microbial activity.
Precursor for sulfoxide/sulfone-containing UV-absorbers and optical brighteners.
Model substrate for mechanistic studies on α-thio ketone photochemistry and metal-catalysed C–S bond activation.
Quality specification (commercial grade):
Purity (HPLC): ≥98 %
Water content (KF): ≤0.3 %
Free thiol (as 3-MeO-PhSH): ≤0.2 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Causes skin and eye irritation (H315 + H319). Avoid inhalation of dust; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants. SDS available on request.
