2-Amino diphenyl sulfide is an aromatic amino-thioether in which an amino group is located ortho to the sulfur bridge. The compound is air-stable, freely soluble in dichloromethane, chloroform, ethyl acetate and acetone, and practically insoluble in water.
Key physicochemical data:
Melting point: 58–60 °C
Boiling point: 315 °C / 760 mmHg
Density: 1.18 g cm⁻³ (20 °C, predicted)
pKa (anilinium): ~3.8
Log P (octanol/water): 3.3 (predicted)
Typical uses:
Central intermediate for benzothiazine-1,1-dioxide COX-2 inhibitors after oxidation of the sulfur to sulfone.
Building block for 2-aminodiphenyl sulfoxide/sulfone pharmaceutical impurities and agro-chemical standards.
Internal standard for GC-MS quantitative analysis of amino-thioether residues.
Quality specification (commercial grade):
Purity (HPLC): ≥98 %
Water content (KF): ≤0.3 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Causes skin and eye irritation (R36/37/38). Harmful if swallowed (R22). Avoid inhalation of dust; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants. SDS available on request.
