4-Amino-4'-nitro diphenyl sulfide is an aromatic amino-thioether in which an amino group is located para to the sulfur bridge on one benzene ring, while a nitro group is situated para to the sulfur on the opposite ring. The compound is air-stable, freely soluble in dichloromethane, chloroform, ethyl acetate and acetone, and practically insoluble in water.
Key physicochemical data:
Melting point: 141–143 °C
Predicted boiling point: 375 °C at 760 mmHg
Predicted density: 1.37 g cm⁻³
Predicted log P (octanol/water): 3.1
Flash point: > 180 °C
Typical uses:
Central intermediate for benzothiazine-1,1-dioxide COX-2 inhibitors: the nitro group is reduced to an amine, cyclised and the sulfur oxidised to sulfone.
Building block for diaryl-sulfone pharmaceutical impurities and agro-chemical standards.
Internal standard for GC-MS quantitative analysis of amino-nitro-thioether residues.
Quality specification (commercial grade):
Purity (HPLC): ≥98 %
Water content (KF): ≤0.3 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement: Causes skin and eye irritation (R36/37/38). Avoid inhalation of dust; use gloves, goggles and adequate ventilation. Store in a cool, dry place away from oxidants. SDS available on request.
