2-Nitro diphenyl sulfide is an aromatic thio-ether in which a phenylthio group is located ortho to a nitro substituent on the benzene ring. The compound is air-stable, freely soluble in dichloromethane, chloroform, ethyl acetate and toluene, and essentially insoluble in water.
Key physicochemical data:
Melting point: 80–84 °C
Boiling point: 343 °C / 760 mmHg (predicted)
Density: 1.31 g cm⁻³ (20 °C, predicted)
Flash point: 161 °C
Vapour pressure: 0.00014 mmHg (25 °C)
Typical uses:
Building block for 2-aminodiphenyl sulfide via catalytic hydrogenation, a key intermediate for benzothiazine-1,1-dioxide COX-2 inhibitors .
Starting material for diaryl sulfone pharmaceutical impurities and agro-chemical standards.
Internal standard for GC-MS quantitative analysis of nitro-thioether residues.
Quality specification (commercial grade):
Purity (HPLC): ≥98 %
Water content (KF): ≤0.3 %
Residue on ignition: ≤0.1 %
Heavy metals: ≤20 ppm
Hazard statement:
Suspected of causing genetic defects (H341). Causes skin and eye irritation (H315 + H319). Avoid inhalation of dust; use gloves, goggles and adequate ventilation. Store locked up. SDS available on request .
