2-Methyl thioanisole is an aromatic thio-ether in which a methylthio group is located ortho to the methoxy substituent on the benzene ring. The compound is air-stable, miscible with most common organic solvents (dichloromethane, ethyl acetate, methanol, ethanol), and essentially insoluble in water.
Key physical data:
Density (20 °C): 1.05 g cm⁻³
Refractive index n²⁰/D: ≈1.58
Boiling point: 188 °C / 760 mmHg
Flash point: 73 °C
Log P (predicted): 2.9
Typical uses:
Starting material for the synthesis of substituted benzaldehydes and phenylacetic acids used in anti-inflammatory and analgesic drug candidates .
Precursor to 2-methylthioaryl boronic acids via ortho-lithiation/borylation, which are key building blocks for cross-coupling reactions .
Internal standard for GC-MS quantitative analysis of methoxy-thioanisole isomers in environmental samples.
Quality specification (commercial grade):
Purity (GC): ≥98 %
Water content (KF): ≤0.2 %
Free phenol: ≤0.5 %
Residue on ignition: ≤0.1 %
Hazard statement:
Causes skin and eye irritation; harmful if inhaled. Use gloves, goggles and adequate ventilation. SDS available on request.
