2-Fluorothioanisole is a fluorinated aromatic sulfide that remains liquid down to –20 °C and distils at 172 °C (760 mm Hg). The material is employed in three main areas:
Pharmaceutical & agro-chemical intermediate – Serves as the key precursor to the anti-inflammatory agent flurbiprofen and to the fungicide flusulfamide after further fluorination or nitration steps.
OLED & opto-electronic materials – Palladium-catalysed C–S or C–N cross-coupling converts the methylthio group into diaryl-sulfides or diaryl-amines that function as electron-transport or hole-blocking layers in small-molecule OLED devices.
Flavour & fragrance building block – FEMA-GRAS 4693, used at 0.1–5 mg kg⁻¹ to impart a spicy, woody, sawdust note to meat seasonings and oriental perfumes.
The product is essentially non-volatile (vapour pressure 0.7 mm Hg @ 25 °C) but has a persistent odour; store under nitrogen at 2–8 °C. It is harmful if swallowed (rat oral LD₅₀ 560 mg kg⁻¹) and is irritating to skin and eyes; handle with gloves and local exhaust ventilation.
