para-Bromo benzyl thiol combining a soft nucleophilic –SH with an aryl-bromide handle. It is a versatile building block for:
Pharmaceutical intermediates – Pd-catalysed thio-arylation affords 4-bromo-aryl sulfide scaffolds used in kinase inhibitors and anti-cancer Ras analogues ;
Agro-chemicals – Cu-coupling gives 4-bromo-aryl sulfide intermediates for rice-blast fungicides and herbicides;
SERS-active SAMs on gold, where the para-bromine lowers surface defect density by 20 %, enhancing mercury-ion detection sensitivity;
RAFT chain-transfer agent for living polymerisation; the aryl-bromide allows post-polymerisation modification via Suzuki or Sonogashira coupling;
Thiol-ene optical resins – high-refractive-index poly(aryl sulfide) films (nD ≈ 1.68) for 5G lens substrates and OLED encapsulation.
Store under nitrogen at 2–8 °C, away from light and oxidants .
